Tesamorelin vs CJC-1295: what is the difference?
Tesamorelin and CJC-1295 belong to the same family: both are GHRH analogues. The difference lies in their structure and in how long they stay stable in research. Below they sit side by side, strictly in a research context.
| Property | Tesamorelin | CJC-1295 with DAC |
|---|---|---|
| Family | GHRH analogue | GHRH analogue |
| Structure | Stabilised analogue of the full GHRH molecule | GHRH fragment with a Drug Affinity Complex (DAC) |
| Distinguishing feature in research | Stabilisation through a structural modification | DAC is designed for slower breakdown |
| Research field | Growth-hormone axis, metabolic research | Growth-hormone secretagogues |
| Purity | ≥99% (HPLC + MS, Janoshik COA per batch) | ≥99% (HPLC + MS, Janoshik COA per batch) |
| Molecular weight | See COA per batch | See COA per batch |
| Vial strength | 10 mg per vial | 5 mg per vial |
Two GHRH analogues, two design choices
Both mimic growth-hormone-releasing hormone, but solve the same problem differently: how do you keep a GHRH-like molecule stable enough to study? Tesamorelin is a stabilised analogue of the full GHRH molecule; CJC-1295 uses a GHRH fragment with a Drug Affinity Complex.
Want the family overview? Read the hub on growth-hormone peptides, or the individual guides to tesamorelin and CJC-1295.
With or without DAC
CJC-1295 comes in two variants: with DAC and without DAC (also called Mod GRF 1-29). The variant without DAC is a different object of study from the DAC variant above; which one is relevant follows from the research design.
See CJC-1295 no DAC, or the full range in muscle growth & growth hormone.
Frequently Asked Questions
What is the difference between tesamorelin and CJC-1295?
Both are GHRH analogues. Tesamorelin is a stabilised analogue of the full GHRH molecule; CJC-1295 is a GHRH fragment designed with a Drug Affinity Complex (DAC) to break down more slowly.
Are tesamorelin and CJC-1295 the same type of peptide?
They belong to the same family (GHRH analogues) but are different molecules with their own structure. In research they are therefore treated as separate objects of study.
What does DAC mean?
DAC stands for Drug Affinity Complex, a modification designed to make the molecule break down more slowly. CJC-1295 exists in a variant with and a variant without DAC.
FOR RESEARCH USE ONLY. For laboratory and research purposes only. Not for human or animal consumption; not a medicine and does not constitute medical advice.