Semaglutide vs tirzepatide vs retatrutide: the difference
These three names are often listed together, but they sit in very different frameworks. Semaglutide and tirzepatide are registered medicines in the EU; retatrutide is a research peptide. Below, purely for information, the difference in receptor profile — without medical claims.
| Property | Retatrutide | SemaglutideNot in our range | TirzepatideNot in our range |
|---|---|---|---|
| Receptor profile (literature) | GLP-1, GIP and glucagon (triple) | GLP-1 (single) | GLP-1 and GIP (dual) |
| Status in the EU | Research peptide, not an approved medicine | Registered medicine | Registered medicine |
| At Peptide Lab | Yes — for research only | No — we do not supply this | No — we do not supply this |
| Research field | Metabolic research | Not applicable | Not applicable |
| Purity | ≥99% (HPLC + MS, Janoshik COA per batch) | Not applicable | Not applicable |
| Molecular weight | See COA per batch | — | — |
| Vial strength | 30 mg per vial | — | — |
Why these three are named together
The connecting theme is the receptor profile: all three act on the GLP-1 receptor, but retatrutide is described in the literature as triple (GLP-1, GIP and glucagon) and tirzepatide as dual. That is pharmacological classification, not a statement about effect or suitability.
Important for the framework: semaglutide and tirzepatide are registered medicines in the EU. Peptide Lab does not supply them and gives no medical advice about them. They appear here for comparison only.
What Peptide Lab does supply
Of these three, only retatrutide is available from us, for laboratory and research purposes only. It is not an approved medicine and not intended for human or animal consumption.
More background in what is retatrutide and retatrutide vs tirzepatide, or see the fat loss & metabolism category.
Frequently Asked Questions
What is the difference between semaglutide, tirzepatide and retatrutide?
The difference described in the literature lies in the receptor profile: semaglutide is single (GLP-1), tirzepatide dual (GLP-1 and GIP) and retatrutide triple (GLP-1, GIP and glucagon). Semaglutide and tirzepatide are registered medicines in the EU; retatrutide is a research peptide.
Does Peptide Lab supply semaglutide or tirzepatide?
No. Those are registered medicines in the EU and we do not supply them. Of these three, only retatrutide is available from us, for laboratory and research purposes only.
Is retatrutide a medicine?
No. Retatrutide is not an approved medicine and is offered for research purposes only, not for human or animal consumption.
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FOR RESEARCH USE ONLY. For laboratory and research purposes only. Not for human or animal consumption; not a medicine and does not constitute medical advice.