Melanotan 1 vs Melanotan 2: what is the difference?
Melanotan 1 and Melanotan 2 are often confused. Both are synthetic analogues of the body's own hormone alpha-MSH, but their structure differs — and with it their profile as an object of study. Here is the difference, without usage advice.
| Property | Melanotan I | Melanotan II |
|---|---|---|
| Also known as | Afamelanotide | MT2 |
| Structure | Linear alpha-MSH analogue | Cyclic, more compact alpha-MSH analogue |
| Point of focus in research | Melanocortin receptors | Melanocortin receptors |
| Research field | Pigmentation research (melanogenesis) | Pigmentation research (melanogenesis) |
| Purity | ≥99% (HPLC + MS, Janoshik COA per batch) | ≥99% (HPLC + MS, Janoshik COA per batch) |
| Molecular weight | See COA per batch | See COA per batch |
| Vial strength | 10 mg per vial | 10 mg per vial |
Linear versus cyclic
The core difference is structural: Melanotan 1 is a linear analogue of alpha-MSH, Melanotan 2 is cyclic and more compact. That ring structure makes MT2 more stable as a molecule, which makes it a different object of study from MT1.
Both are studied within pigmentation research around the melanocortin receptors and melanogenesis — the process by which melanin is formed. More background in what is Melanotan 2.
Research framework
Neither is an approved medicine, and both are supplied for laboratory and research purposes only. No health or usage claims are attached to them, and this is not dosing or usage advice.
See both in the skin & pigmentation category.
Frequently Asked Questions
What is the difference between Melanotan 1 and Melanotan 2?
Melanotan 1 (afamelanotide) is a linear analogue of alpha-MSH; Melanotan 2 is a cyclic, more compact analogue. Both are studied in pigmentation research, but they are different molecules with their own profile.
Is Melanotan 2 the same as MT2?
Yes, MT2 is the common abbreviation for Melanotan 2. Melanotan 1 is also called afamelanotide in the literature.
Are Melanotan 1 and 2 approved medicines?
No. Both are offered by Peptide Lab for laboratory and research purposes only and are not intended for human or animal consumption.
Further reading
FOR RESEARCH USE ONLY. For laboratory and research purposes only. Not for human or animal consumption; not a medicine and does not constitute medical advice.